My Resumé

Education

1996- Associate Professor of Medical Microbiology at the University of Uppsala, Sweden (http://www.uu.se).

1991- PhD (VMD) in Veterinary Microbiology (specialized in Bacteriology) at the Swedish University of Agricultural Sciences, Uppsala, Sweden (http://www.bvf.slu.se).

1985- Research training (cell-cell adhesion) at the Swedish University of Agricultural Sciences, Uppsala, Sweden (http://www.bvf.slu.se).

1983- DVM (Doctor of Veterinary Medicine) with MVSc (Master of Veterinary Sciences) at the Kharkov State Veterinary Academy, Ukraine (http://zoovet.kharkov.ua/eng/index.htm).

1983- Professional Russian language at the Kharkov State Veterinary Academy, Ukraine (http://zoovet.kharkov.ua/eng/index.htm).

1976- Life Science, at Addis Ababa University, Ethiopia (http://www.aau.edu.et).

1974- Secondary School education at Jimma Miazia 27 Comprehensive Secondary School, Ethiopia (http://miaziaalumni.tripod.com/id11.html).

Professional Experience

2004 - present: Associate Principal NeuroScientist at the global Drug Discovery Division, Preclinical Research & Development (R & D), at the AstraZeneca Södertälje, Sweden (http://www.astrazeneca.com).

1998 - present: Monitoring Scientist (Animal welfare inspection) of pre-clinical studies on international CROs.

1998 - 2004: Head of Transgenics at the AstraZeneca Pharmaceuticals Plc, Preclinical R & D, Södertälje, Sweden.

1996 - 1997: Deputy Director of the Department of Veterinary Services, at Astra Arcus Pharmaceuticals Plc, R & D Södertälje, Sweden.

1994 - 1996: Preclinical Study Director on the development of drug against Multiple Sclerosis at Astra Arcus. Pharmaceuticals Plc, R & D, Södertälje, Sweden.

1993 - 1994: Preclinical Study Director on the development of drug against human gastritis at Astra Arcus Pharmaceuticals Plc, R & D, Södertälje, Sweden.

1991 - 1993: Scientific consultant and project leader on a vaccine trial project for Alfa Laval Agri International, at SLU, Uppsala, Sweden.

1986 - 1991: Research Associate at the Department of Veterinary Microbiology at the Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden.

1984: District Veterinary Surgeon in a mixed veterinary practice in Kharkov, Ukraine.

1983 – 1984: Laboratory Veterinarian, at Valky Regional Veterinary Diagnostic Laboratory, Ukraine.

Pedagogical Activities

1993 – present: Periodic lecturing Microbiology (mainly Bacteriology) to medical and Bio-Medical undergraduate students, to veterinary students

1983 - 1984: Teaching/training veterinarians on different laboratory diagnostic methods

Major Research Experience

· Wide experience (over 20 years) working with microbes and microbial (bacterial/viral) infections in the clinics and laboratory.

· Vaccine (recombinant vaccines) against staphylococcal and streptococcal infections, construction, immunization (vaccination), challenge and evaluation of toxicity and efficacy.

· Neuropathology: Alzheimer, Stroke, Multiple Sclerosis.

· Dementia (age-related), cognitive impairment, behaviours analysis

· Fertility: In vitro fertilization (IVF) in mice model.

· Cryobiology: Low temperature studies of biological systems

· Manipulation of pre-implantation embryo and germ cells.

· DNA analysis (genotyping) by PCR and phenotype.

· Leading research projects dealing with intra-mammary infections.

· Scientific supervision of researchers, graduate students, visiting scientists and research veterinarians working on the pathogenesis of bacterial infections.

· Coordinating and management of pre-clinical studies globally at international CROs.

· Non-clinical safety studies, OEDC, GLP principles & FDA and GLP regulations.

Innovation

· Inventor of a “Methodology to identify therapeutically active compounds” in preclinical studies. Patent internationally filed.

· Identified a novel surface antigen a “vaccine candidate antigen” on S.aureus causing intra-mammary infections.

Trainings & Courses

· Range ecology management and livestock production

· Experimental animals management, experimentation in target discovery and validation; Ethics and animal experiments

· Genetics and advanced functional genomics

· Genetically modified (Transgenic) animal models

· Drug toxicity and efficacy evaluation

· Non-clinical safety studies

· Embryology; embryo transfer; Cryopreservation (low temperature biology) of embryos

· Human cells and cell culturing

· Statistics in biomedical research

· Women empowerment and gender issues

· Ethic & animal experimentation in pharmaceutical industries.

Participations on Scientific Conferences and Workshops

I was invited and presented research papers and other development associated reports on numerous international conferences, congresses, and workshops. I also organized and chaired international workshops on urban development initiatives.

Invited presentations, selected (since 1992)

· VII-th International Symposium on Staphylococci and Staphyloccal Infections. Stockholm, Sweden, 29 June-3 July 1992.

· VIII-th International Workshop on Immunodeficient Animals. Utrecht, Netherlands, July 3-7, 1994.

· XIII-th International Conference on Ethiopia Studies, Kyoto, Japan, Dec., 12-17 1997.

· International Conference on the use of humane endpoints in animal experiments for biomedical research, Zeist, The Netherlands, Nov, 22-25, 1998.

· First International Conference on AIDS in Ethiopia: Fighting for life, Addis Ababa, Ethiopia, Nov 7-10, 1999.

· Behavioural phenotyping of mouse mutants, Cologne, Germany, Feb. 17-19, 2000.

· Annual Meeting on Bacterial Adhesion. Uppsala, Sweden, January 26, 1991.

· Symposium on Advanced Wound Care/Medical Research Forum on Wound Repair. New Orleans, U.S.A., Apr., 23-25, 1992.

· VIII-th International Congress of Immunology: Transmembrane signalling in the immune system, Debrecen, Hungary, Aug., 18-22, 1992. .

· VIII-th International Congress of Immunology. Budapest, Hungary, August 23-28, 1992.

· The III-rd International Mastitis Seminar, Tel-Aviv, Israel, May 28-June 1, 1995. Vaccine for the Year 200. Gothenburg, Sweden, Oct., 26-27, 1994.

· VIII-th International Symposium on Staphylococci and Staphylococcal Infections. Aix-Les-Bains, France, June 23-26, 1996.

· International Joint Meeting, XII General Assembly & Conference, 7th FELASA Symposium, Palma de Mallorca, Balearic Islands, Spain, May, 26-28, 1999.

· 30-th Annual Symposium and Educational days of the Scandinavian Society for Laboratory Animal Science, Djurönäset, Stockholm, Sweden, May 4-7, 2000

· 51-th AALAS National meeting, San Diego, USA, Nov, 9-11, 2000

Editorial Board and Board of Directors

· Editorial Board: International Advisory Editorial of The Horn of Africa Journal of AIDS (HAJA). HAJA publishes peer-reviewed articles on all aspects of neurological disease and HIV/AIDS.

· Board of Directors: Board of Directors in The African AIDS Initiative International AAII, an international NGO dedicated to promoting HIV/AIDS awareness in Africa.

· Advisory Board: The Science Advisory Board, (www.scienceboard.net).

Experiences/Contributions in Urban Community Health Development

· Identification of community health problems in the poorest suburbs of Addis Ababa, Ethiopia and analysis of community needs through feasibility studies (pilot programs).

· Assessment of the problem, project and program development & preparation of proposals for funding, effective and sustainable program development and developing monitoring and effectiveness evaluation program.

· Assist emerging/existing non-profit program/projects that their efforts meet community needs, mission and vision statement development, community outreach and promotional campaigns.

· Support urban development projects interpreting urban development policies and programs to the local people.

· Program/project and evaluation: establishing appropriate monitoring and evaluation systems that provide the basis for improving, establishing integrated monitoring and evaluation systems for continuous and periodic assessment of progress at all levels during the program/project period, evaluating the impact, effectiveness and cost-effectiveness of the project interventions.

· Program/project results reporting on international & national conferences & workshops.

· Project appraisal & Co-coordinating a trilateral (Sida/AEHPS/CBISDO) project on the prevention of HIV/AIDS pandemic in Ethiopia. (Sida= the Swedish International Development Agency in Sweden).

· Presentation of results and reports on HIV/AIDS prevention and associated efforts on international & national conferences and workshops (ref: below).

Contributions on HIV/AIDS Prevention and Community Health Development Conferences & Workshops (selected)

· Conference on Structures of Vulnerability: Mobilisation and Resistance", “Health and Vulnerability” workshop, Stockholm, Sweden, 12-14 January 2005. Oral presentation.

Mamo W., Begashaw, B., Wondimu, B. (2005). Holistic approach is vital in tackling HIV/AIDS epidemic in Africa: an experience from Ethiopia. A Sida/AEHPS supported HIV/AIDS prevention project. Susanne Selerud (ed), Conference proceedings, pp 172-73, Stockholm MMIV (www.vulnerability.se/files/Wubshet_Mamo.pdf).

· XV International AIDS Conference. Bangkok, Thailand, 11-16 July 2004.

Wamo W. & B. Wondimu (2004). The role of African health professionals in Diaspora against the spread of HIV/AIDS: Experience & a model from Ethiopia. MedGenMed. 2004 Jul 11; 6 (3): 2004 Jul 11;(1): Poster, (http://www.ias.se/ejias/show.asp?abstract_id=2171783)

· I^st International AIDS Conference in Ethiopia, Addis Ababa, Ethiopia, Nov 7-9, 1999. Chairman of a session (the role of Diaspora Ethiopians) on and also presented a paper on the role of Diaspora Ethiopians health professionals.

Mamo W., Begashaw, B., Maru, F. Wondimu, B. (1999). The Role of Ethiopian Health Professionals residing abroad in the battle against HIV/AIDS pandemic in Ethiopia. An Applicable Model?”; Oral presentation.

· The Journal of American Medical association (JAMA). JAMA, Vol. 282 No. 22, December 8, 1999. "Helping their homeland". On the efforts of AEHHPS in Ethiopia (http://jama.ama-assn.org/cgi/content/extract/282/22/2111).

· V^thInternational Workshop of European partenariat between African communities and health partners for HIV/AIDS prevention. Stockholm, Sweden, September 28-30, 2000.

Mamo W., Maru, F. Wondimu, B. (2000). Ethiopian Health Professionals in Sweden in the Battle against HIV/AIDS Pandemic in Ethiopia: An Experience from the Association of Ethiopian Health Professionals in Sweden (AEHPS);. Oral presentation.

· VI^th International workshop of European partenariat between African communities and health partners for HIV/AIDS prevention. Madrid, Spain January 10-13, 2001.

Wondimu, B & Mamo W (2001). "Cross actions" between sub-Saharan Africa and Europe on the prevention of HIV/AIDS: An experience of The Association of Ethiopian Health Professionals in Sweden (AEHPS) in Ethiopia; Oral presentation.

· XIII^th International Conference on Ethiopian Studies, Kyoto, Japan, December 1997.

Mamo W., Jember, T., Begashaw, B., Moussa, M. (1997). The significant contribution of community development projects in improving community health. An experience from an Integrated and Holistic Community Development Project in Ethiopia. In: Ethiopia in Broader Perspectives, Fuku. K, Kurimoto. E and Sheigeta M (Eds.), pp 721-725, ISBN:4-87974-978-8 C3039; Oral presentation.

Countries of Experience

Ethiopia, Russia, Sweden

Computer Skill and Language Proficiency

Experienced user of hardware and software; word processing skills and knowledge of database/ spreadsheet and execution of international network communications.

Language skill: Read, write and speak fluently Amharic (Ethiopian national language), very good English, Swedish and Russian; fair French and Spanish.

Professional and Public Societies Affiliations (selected)

· International Society for Transgenic Research (ISTR), member

· International Society for Cryobiology (ISC), member (http://www.societyforcryobiology.org)

· Scandinavian Federation of Laboratory Animal Science, member(http://www.med.uib.no/scandlas)

· Swedish Veterinary Association (SVA), member (http://www.svf.se )

· Association of Ethiopian Health and health related professionals in Sweden (AEHHPS), board member (http://aehhps.tripod.com)

· People to people anti AIDS organization (P2P), member (http://www.peoplepeople.org)

· Alumni association, chairman (http://miaziaalumni.tripod.com)

Achievement

Built a full operational Transgenic Facility at Astrazeneca, preclinical R & D, Södertälje, Sweden.

Publications (Refereed Journals)

1) Mamo, W., Fröman Gunnar and Müller, H-P. (2000). Protection induced in mice vaccinated with recombinant Collagen-binding protein (CnBP) and alpha-toxoid against intramammary infection with Staphylococcus aureus. Microbiology & Immunology, 44:5:381-384.

2) Mamo, W. (1999). Application of a mouse mastitis model for evaluation of antigen vaccines against Staphylococcus aureus -induced mastitis. Scand. J. Lab. Anim. Sci. 3:26:124-129.

3) Mamo, W., Jonsson, P. and Müller, H-P. (1995). Opsonization of Staphylococcus aureus with a fibronectin-binding protein antiserum induces protection in mice. Microbiol. Pathogen, 19:49-55.

4) Mamo, W., Jonsson, P., Flock, J-I., Müller, H-P. (1995). Induced immunological response of mice vaccinated with fibronectin-binding-proteins and fibrinogen-binding proteins against Staphylococcus aureus mastitis. Proceedings in The III-rd International Mastitis Seminar, Tel-Aviv, Israel, May 28-June 1, 1995; SI:86-89.

5) Mamo, W. and Fröman, G. (1994). In vivo-like antigenic surface properties of S. aureus from bovine mastitis induced upon growth in milk whey. Microbiology and Immunology, 38:10:801-4.

6) Mamo, W., Bodén, M. and Flock, J-I. (1994). Vaccination with Staphylococcus aureus fibrinogen-binding proteins (FbBPs) reduces colonization of S. aureus in a mouse mastitis model. FEMS Immunol. and Medical Microbiol. 10:47-54.

7) Mamo, W., Jonsson, P., Flock, J-I., Lindberg, M., Müller, H. P., Wadström, T. and Nelson, L. (1994). Vaccination against S. aureus mastitis: Immunological response of mice vaccinated with fibronectin-binding proteins (FnBps) to challenge with S. aureus. Vaccine, 12:11:988-992.

8) Mamo, W., and Fröman, G. (1994). Adhesion of Staphylococcus aureus to bovine mammary epithelial cells induced after growth in milk whey. Microbiology and Immunology. 38:305-308.

9) Mamo, W., Fröman, G. (1994). Binding of Staphylococcus aureus to extracellular matrix fibronectin and collagen in relation to wound infection. Wounds, 6 (3):88-93.

10) Mamo, W., Lindahl, M., Jonsson, P. (1993). Binding of fibronectin and type II collagen to Staphylococcus aureus: Reduction of binding caused by a periodate-sensitive surface structure induced after growth in milk whey. Wounds. 5:62-65.

11) Mamo, W., Lindahl, M., and Jonsson, P. (1992). Binding of fibronectin and type II collagen to Staphylococcus aureus from bovine mastitis: Reduction of binding after growth in milk whey. Microb. Pathogen. 12:443-449.

12) Sandgren, C.H., Mamo, W., Larsson, I., Lindahl, M. and Björk, I. (1991). A periodate-sensitive anti-phagocytic surface structure, induced by growth in milk whey on Staphylococcus aureus from bovine mastitis. Microb. Pathogen. 11:211-220.

13) Mamo, W. (1991). Mastitframkallande formåga hos S.aureus vid odling i mjölkvassle Svensk Veterinär Tidning, 43:407-409.

14) Mamo, W., Lindahl, M. and Jonsson, P. (1991). Enhanced virulence of Staphylococcus aureus from bovine mastitis induced by growth in milk whey. Vet. Microbiol. 27:371-384.

15) Mamo, W., Sandgren, C. H., Lindahl, M. and Jonsson, P. (1991). Induction of anti-phagocytic surface properties of Staphylococcus aureus from bovine mastitis by growth in milk whey. J. Vet. Microbiol.B, 38:1-10.

16) Rozgonyi, F., Mamo, W., Fröman, G., Ljungh, Å., Hjertén, S. and Wadström, T. (1990). Cell surface hydrophobicity and serum-protein bindings of Methicilline-resistant and-susceptible staphylococcal strains. Zbl. Bakt. Suppl. 21:123-125.

17) Jonsson, P., Mamo, W. and Lindahl, M. (1989). Surface properties of Staphylococcus aureus related to virulence in bovine mastitis. In: Proceedings of International Conference on Mastitis, St. Georgen, Austria, 29 May - 2 June, 1989, pp. 135-140.

18) Mamo, W. (1989). Physical and biochemical surface properties of Gram- positive bacteria in relation to adhesion to bovine mammary cells and tissues. Rev. Sci. Tech. Off. Int. Epiz., 1:163-176.

19) Jarp, J., Mamo, W. and Johne, B. (1989). Surface properties of Staphylococcus aureus isolated from caprine mastitis. Acta. Vet. Scand. 30:335-339.

20) Mamo, W., Fröman, G. and Wadström T. (1988). Interaction of subepithelial connective tissue components with Staphylococcus aureus and coagulase-negative staphylococci from bovine mastitis. Vet. Microbiol. 18:163-176.

21) Mamo, W., Sundås, A., Fröman, G. and Wadström, T. (1987). Binding of fibronectin, fibrinogen and type II collagen to streptococci isolated from bovine mastitis. Microb. Pathogen. 2:417-424.

22) Mamo, W., Rozgonyi, F., Hjertén, S. and Wadström, T. (1987). Effect of milk on surface properties of Staphylococcus aureus from bovine mastitis. FEMS Microbiol. Letts. 48:195-200.

23) Mamo, W., Rozgonyi, F., Brown, A., Hjertén, S. and Wadström, T. (1987). Cell-surface hydrophobicity and charge of Staphylococcus aureus and coagulase-negative staphylococci isolated from bovine mastitis. J. Appl. Bact. 62:241-249.

24) Mamo, W., & Wadström, T. (1986). Fibronectin, fibrinogen and type II collagen binding to streptococci isolated from bovine mastitis. In: Proceedings of Symposium on Mastitis and Hygienic Production of Milk. Marcus Sandholm (ed.). Vammalan Kirjapaino Oy, Vammala, pp. 87-89.

25) Mamo, W., Fröman, G. & Wadström, T. (1986). Bacterial adhesion as a Virulence factors in bovine mastitis: Possible role of surface hydrophobicity, capsule, fibronectin, fibrinogen and collagen binding. In: Proceedings of Symposium on Mastitis and Hygienic Production of Milk. Marcus Sandholm (ed.). Vammalan Kirjapaino Oy, Vammala, pp. 77-87.

Articles On books

1) Mamo, W., Sandgren, C. H., Jonsson, P., Lindahl, M. and Kenne, L. (1994). Induction of anti-phagocytic carbohydrate surface structure and enhancement of virulence of S. aureus from bovine mastitis by growth in milk whey. In: Staphylococci and Staphylococcal Infection, Mölby R. and Flock J-I. (Eds.), Gustav Fischer Verlag, Stuttgart, Jena, New York, pp. 519-523.

2) Mamo, W., Schennings, T. and Flock, J-I. (1994). Vaccination against S. aureus infection using a fibronectin binding protein. In: Staphylococci and Staphylococcal Infection, Mölby R. and Flock J-I. (eds.), Gustav Fischer Verlag, Stuttgart, Jena, New York, pp. 555-558.

3) Rozgonyi, F., Ljungh, Å., Mamo, W., Hjertén, S. and Wadström, T. (1990). Bacterial cell surface hydrophobicity. In: Pathogenesis of Wound and Biomaterial-Associated Infections. Wadström, T., Eliasson, I., Holder, I. and Ljungh, Å. (eds.), Springer Verlag, London, New York, pp. 233-244.

Dissertations

PhD (VMD) thesis:

Mamo, W. (1991). Bovine Mastitis Pathogens: Studies on cell-matrix protein-binding and induction of potential virulence determinants of Staphylococcus aureus. Swedish University of agricultural Sciences. Ph.D. thesis, ISBN 91-576-4446-2, Uppsala, Sweden; http://agricola.nal.usda.gov/cgi-bin/Pwebrecon.cgi?Search_Arg=Mamo+wubshet&Search_Code=NAME_&PID=20075&CNT=10&BROWSE=1&HC=1&SID=2).

MVSc thesis:

Mamo, W. (1983). Laboratory Diagnosis, Specific Prophylaxis and Control of Mass Respiratory Diseases in Cattle. MVSc thesis, Department of Microbiology, and Virology, Kharkov State Veterinary Academy, Ukraine (http://zoovet.kharkov.ua/eng/index.htm).